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KMID : 0360319940260060901
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Journal of Korean Cancer Research Association
1994 Volume.26 No. 6 p.901 ~ p.911
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The Expression of c-erbB-2 Oncoprotein and Epidermal Growth Factor Receptro(EGFR) in Breast Cnacer Patients in Korea
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박원
백남선/김용규/문난모/이종인/최동욱/황대용/장자준
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Abstract
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Samples of breast carcinoma were collected from 117 patients who underwent mastectomy in Korea Cancer Center Hospital from Jan. 1982 to Dec. 1984. We studied expression of the c-erbB-2 oncoprotein and EGFR with the immunohistochemical technique.
We
also
analyzed to clarify the relationship between expression of the c-erbB-2 oncoprotein and/or EGFR and tumor size, node metastasis, stage, histologic grade, TIL, and EIC, and to evaluate the prognostic significance of c-erbB-2 oncoprotein and EGFR
in
breast cancer. EGFR expression rate was 37.6%(44/117) and EGFR status had positive correlation with histologic grade(p<0.05). But, we did not find any other relationship with other clinicopathological prognostic factors. C-erbB-2 expression rate
was
64.1%(71-117). There was no relevance between c-erbB-2 expression and other prognostic factors. Higher histologic grade was poorer survival rate. EGFR positive patients had poorer prognosis than negative patients in stage I and Ⅱbreast
cancer(p<0.05).
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KEYWORD
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